منابع مشابه
Facilitating efferent inhibition of inner hair cells in the cochlea of the neonatal rat.
Cholinergic brainstem neurones make inhibitory synapses on outer hair cells (OHCs) in the mature mammalian cochlea and on inner hair cells (IHCs) prior to the onset of hearing. We used electrical stimulation in an excised organ of Corti preparation to examine evoked release of acetylcholine (ACh) onto neonatal IHCs from these efferent fibres. Whole-cell voltage-clamp recording revealed that low...
متن کاملEditorial: Auditory Efferent System: New Insights from Cortex to Cochlea
1 Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile, 2 Departamento de Otorrinolaringología, Hospital Clínico de la Universidad de Chile, Santiago, Chile, 3 Facultad de Medicina, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres (INGEBI), Consejo Nacional de Invest...
متن کاملOnset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea.
In the developing mammalian cochlea, the sensory hair cells receive efferent innervation originating in the superior olivary complex. This input is mediated by α9/α10 nicotinic acetylcholine receptors (nAChRs) and is inhibitory due to the subsequent activation of calcium-dependent SK2 potassium channels. We examined the acquisition of this cholinergic efferent input using whole-cell voltage-cla...
متن کاملDegeneration in the Efferent Nerve Endings in the Cochlea after Axonal Section
Both roots of the olivo-cochlear nerve bundle to one ear were transected in the brain stems of 12 chinchillas. The animals were sacrificed at times ranging from 2 to 35 days after surgery. The normal olivo-cochlear terminals on the external hair cells in the cochleas of the control ears contained many mitochondria and small vesicles of constant size. The earliest evidence for degeneration was t...
متن کاملEfferent synapses return to inner hair cells in the aging cochlea.
Efferent innervation of the cochlea undergoes extensive modification early in development, but it is unclear if efferent synapses are modified by age, hearing loss, or both. Structural alterations in the cochlea affecting information transfer from the auditory periphery to the brain may contribute to age-related hearing deficits. We investigated changes to efferent innervation in the vicinity o...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2018
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a033530